USD 25 SUSTANON 250 250MG/ML SOLUTION FOR INJECTION. TESTOSTERONE ( DECANOATE 100MG / ISOCAPROATE 60MG / PHENYLPROPIONATE 60MG / PROPIONATE 30MG)

SUSTANON 250 250MG/ML SOLUTION FOR INJECTION BY ZYDUS HEALTHCARE (Cadila Healthcare) 1ml capsules.

Active substance(s): TESTOSTERONE DECANOATE 100 MG / TESTOSTERONE ISOCAPROATE 60 MG / TESTOSTERONE PHENYLPROPIONATE 60 MG / TESTOSTERONE PROPIONATE 30 MG

What Sustanon 250 contains
The active substance is:
Each milliliter of the oily solution contains the following:
30 mg testosterone propionate,
60 mg testosterone phenylpropionate,
60 mg testosterone isocaproate,
100 mg testosterone decanoate,

All four compounds are esters of the natural hormone testosterone.

Package Leaflet: Information for the patient
Sustanon 250, 250 mg/ml, solution for injection
(testosterone esters)

What is in this leaflet:
1. What Sustanon 250 is and what it is used for
2. What you need to know before Sustanon 250 is administered
3. How Sustanon 250 is administered
4. Possible side effects
5. How to store Sustanon 250
6. Contents of the pack and other Information

1. WHAT SUSTANON 250 IS AND WHAT IT IS USED FOR

Sustanon 250 is a clear pale yellow solution for injection containing the active ingredient
testosterone in 4 (250 mg/ml) separate forms. The active substances of Sustanon 250 (see
section 6 “What Sustanon 250 contains” are turned into testosterone by your body. Testosterone
is a natural male hormone known as an androgen.
In men, testosterone is produced by the testicles. It is necessary for the normal growth,
development and function of the male sex organs and for secondary male sex characteristics. It is
necessary for the growth of body hair, the development of bones and muscles, and it stimulates
the production of red blood cells. It also makes men’s voices deepen.
Sustanon 250 is used in adult men for testosterone replacement to treat various health problems
caused by a lack of testosterone (male hypogonadism). This should be confirmed by two
separate blood testosterone measurements and also include clinical symptoms such as
impotence, infertility, low sex drive, tiredness, depressive moods and bone loss caused by low
hormone levels.
Sustanon 250 may also be used as supportive therapy for female-to-male transsexuals.

2. WHAT YOU NEED TO KNOW BEFORE SUSTANON 250 IS ADMINISTERED

Do not take Sustanon 250:
If you are pregnant or think you may be pregnant (see “Pregnancy, breast-feeding and fertility”).
If you have or have had a tumour of your prostate or breast, or are suspected to have one of
these tumours.
In children under the age of 3 years.
If you are allergic to one or more of the ingredients of this medicine (listed in section 6 “What
Sustanon 250 contains”).If you are allergic to peanuts or soya (see Section 2 “Important
information about some of the ingredients of Sustanon 250”).

Take special care with Sustanon 250:
If you notice any signs of masculinisation (for instance lowering of the voice or increase in body or
facial hair), consult your doctor immediately.
Treatment with male hormones like testosterone may increase the size of the prostate gland,
especially in elderly men. Therefore your doctor will examine your prostate gland at regular
intervals by digital rectal examination (DRE) and blood tests for prostate-specific antigen (PSA).
Additionally, at regular intervals, blood tests will be done to check the oxygen-carrying substance
in your red blood cells (haemoglobin). In very rare cases the number of red blood cells will
increase too much leading to complications.
The following blood checks should be carried out by your doctor before and during the treatment:
testosterone blood level, full blood count.
Medical checks may also be necessary in some other conditions. Therefore, before you start
using this medicine you must tell your doctor or pharmacist if you ever had, still have or are
suspected to have:
Breast cancer which has spread to the bones;
Kidney or lung cancer;
Heart disease;
Kidney disease;
Liver disease;
High blood pressure;
Diabetes mellitus;
Epilepsy;
Migraine, headaches;
Prostatic complaints, such as problems with passing urine;
Blood clotting problems – thrombophilia (an abnormality of blood coagulation that increases the
risk of thrombosis – blood clots in blood vessels).

If you are suffering from severe heart, liver or kidney disease, treatment with Sustanon 250 may
cause severe complications in the form of water retention in your body sometimes accompanied
by (congestive) heart failure.
Tell your doctor if you have high blood pressure or if you are treated for high blood pressure as
testosterone may cause a rise in blood pressure.
If you have sleep apnoea (temporarily stopping breathing during your sleep), it may get worse if
you are using testosterone-containing products. Let your doctor know if you are worried about
this. Extra supervision by your doctor may be necessary in case you are overweight or suffer from
chronic lung disease.
During treatment you should also tell your doctor:
if you are a female-to-male transsexual. You should have special assessments, including
psychiatric assessment, before treatment is started.
if you are a female-to-male transsexual and have a personal or family history of breast
cancer and a personal history of endometrial cancer.
Children and adolescents
The safety and efficacy of this medicine has not been adequately determined in children and
adolescents.

Extra supervision by your doctor is necessary in the treatment of children and adolescents since
testosterone administration in general may cause early sexual development and limits growth
(see section 4 “Children and adolescents”).
Blood tests may be affected.
For female-to-male transsexuals, Sustanon 250 may be given as part of a programme of
treatment, including surgery.

Other medicines and Sustanon 250
→Please tell your doctor or pharmacist if you are taking, have recently taken, or might take any
other medicines – even those not prescribed.
Other medicines may influence the effects of Sustanon 250, or Sustanon 250 may affect other
medicines. Therefore you must tell your doctor or pharmacist if you are using, or are about to use:
Insulin and/or other medicines to control blood sugar levels;
Medicines to reduce the clotting of your blood (anti-coagulants);
Certain medicines that change the amount of enzymes to be made in the liver e.g. medicines
used to treat epilepsy (phenobarbital).
These drugs may affect the levels of testosterone in your body and your doctor may need to
adjust the dose or frequency of your Sustanon 250.
The use of androgens like Sustanon 250 may lead to a reduction of the doses of these
medicines.
Also tell your doctor or pharmacist if you are using or about to use the hormone ACTH or
corticosteroids (used to treat various conditions such as rheumatism, arthritis, allergic conditions
and asthma). The use of androgens like Sustanon 250 may increase the risk of water retention
especially if your heart and liver are not working properly.
Androgens may also affect the results of some laboratory tests (e.g. thyroid gland). Therefore you
must tell your doctor or the laboratory staff performing the tests that you are using this medicine.
Using Sustanon 250 with food and drink
This medicine can be injected without taking consideration of meals and drinks.
Pregnancy, breast-feeding and fertility
Sustanon 250 must not be taken by women who are pregnant or think they are pregnant (see
section 2 “Do not use Sustanon 250”), or by women who are breast-feeding.
In men, treatment with Sustanon 250 can lead to fertility disorders by repressing sperm formation.
In women, treatment with this medicine can lead to an irregular or absent menstrual cycle.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby,
ask your doctor or pharmacist for advice before taking this medicine.

Driving and using machines
As far as is known this medicine has no influence on driving and using machines.
Important information about some of the ingredients of Sustanon 250
This medicine also contains:
Arachis oil (peanut oil) – If you are allergic to peanut or soya, do not use this medicinal
product (see “Do not use Sustanon 250”).

Benzyl alcohol (100 mg per ml of solution) – Products containing benzyl alcohol must not
be given to premature babies or neonates. Benzyl alcohol may cause toxic reactions and
allergic reactions in infants and children up to 3 years old.

Improper use
If you are a patient who participates in competitions governed by the World Anti-Doping Agency
(WADA), then you should consult the WADA-code before using this medicine as Sustanon 250
can interfere with anti-doping testing.
The misuse of this medicine to enhance ability in sports carries serious health risks and is
discouraged.

3. HOW SUSTANON 250 IS ADMINISTERED

Usually, the dosage is one injection of 1 ml every three weeks.
Use in children and adolescents
The safety and efficacy of this medicine have not been adequately determined in children and
adolescents. Pre-pubertal children using this medicine will be monitored by your doctor (see
section 2 “Take special care with Sustanon 250”).
If you use more Sustanon 250 than you should
The following effects may happen:
• Frequent erections in men;
• Changes in your red blood cells (polycythaemia), which your doctor may monitor you for.

Effects when treatment with Sustanon 250 is stopped
The effects of this medicine do not stop immediately after discontinuation, but gradually subside.
When treatment with this medicine is stopped, complaints such as those experienced before
treatment may re-occur within a few weeks.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Adults (female-to-male transsexuals)
Sustanon 250:
Doses vary from one injection of 1 ml every two weeks to one injection of 1 ml every four weeks.

4. POSSIBLE SIDE EFFECTS

Like all medicines, Sustanon 250 can have side effects although not everybody gets them. In
general the side effects which are reported with testosterone therapy include:
Common (may affect up to 1 in 10 people)
Increase in red blood cell count (the cells which carry the oxygen in your blood); haematocrit
(percentage of red blood cells in blood) and haemoglobin (the component of red blood cells
that carries oxygen), identified by periodic blood tests.

5. HOW TO STORE SUSTANON 250

Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date stated on the carton or label after the term “exp”
(expiry date). The expiry date refers to the last day of that month.
Store below 30°C. Do not refrigerate or freeze.
Store in the original package in order to protect from light.
Do not throw away any medicines via wastewater or household waste. Ask your Pharmacist how
to throw away medicines you no longer use. These measures will help to protect the environment.

6. CONTENTS OF THE PACK AND OTHER INFORMATION

What Sustanon 250 contains
The active substance is:
Each milliliter of the oily solution contains the following
testosterone propionate,
30 mg
testosterone phenylpropionate,
60 mg
testosterone isocaproate,
60 mg
testosterone decanoate,
100 mg
All four compounds are esters of the natural hormone testosterone.

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